2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. EP1-antagonist-1

EP1-antagonist-1 is a EP1 antagonist with a pKi of 7.54 and an pIC50 of 8.5.

For research use only. We do not sell to patients.

EP1-antagonist-1 Chemical Structure

EP1-antagonist-1 Chemical Structure

CAS No. : 851204-35-8

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1 mg USD 239 In-stock
5 mg USD 480 In-stock
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EP1-antagonist-1 Related Antibodies

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Description

EP1-antagonist-1 is a EP1 antagonist with a pKi of 7.54 and an pIC50 of 8.5[1].

IC50 & Target

pIC50: 8.5 (EP1)[1]

pKi: 7.54 (EP1)[1]
Molecular Weight

470.14

Formula

C19H15BrCl2N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN(CC2=CC(Br)=CC=C2OCC3=CC=C(Cl)C=C3Cl)C(C)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 55 mg/mL (116.99 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1270 mL 10.6351 mL 21.2703 mL
5 mM 0.4254 mL 2.1270 mL 4.2541 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.60%

COA (252 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1270 mL 10.6351 mL 21.2703 mL 53.1756 mL
5 mM 0.4254 mL 2.1270 mL 4.2541 mL 10.6351 mL
10 mM 0.2127 mL 1.0635 mL 2.1270 mL 5.3176 mL
15 mM 0.1418 mL 0.7090 mL 1.4180 mL 3.5450 mL
20 mM 0.1064 mL 0.5318 mL 1.0635 mL 2.6588 mL
25 mM 0.0851 mL 0.4254 mL 0.8508 mL 2.1270 mL
30 mM 0.0709 mL 0.3545 mL 0.7090 mL 1.7725 mL
40 mM 0.0532 mL 0.2659 mL 0.5318 mL 1.3294 mL
50 mM 0.0425 mL 0.2127 mL 0.4254 mL 1.0635 mL
60 mM 0.0355 mL 0.1773 mL 0.3545 mL 0.8863 mL
80 mM 0.0266 mL 0.1329 mL 0.2659 mL 0.6647 mL
100 mM 0.0213 mL 0.1064 mL 0.2127 mL 0.5318 mL
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EP1-antagonist-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EP1-antagonist-1851204-35-8Prostaglandin ReceptorInhibitorinhibitorinhibit

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